VLP (Virus Like Particle) Production Services

Virus like particles (VLPs) represent tremendous potential as vaccine candidates in development of therapeutics for infectious diseases. VLPs possess significant advantages by mimicking the three-dimentional conformation of a natural virus but are non-infectious because of lacking any viral genome packaged inside the capsid.

AscentGene offers VLP production services through our upgraded baculovirus system through the self-assembly mechanism. Ascentgene has been successfully producing high titer (4×1013vlps/ml), high quality (>99% pure) and high activity VLPs with high yield (2 x 1014vlps/L culture) by using either CsCl gradient or chromatography protocols.

Available VLP assays:

A) Hemagglutination assay (HA) to analyze VLP’s activity

B) Electron microscopy (EM) to detect VLP’s conformation

C) Enzyme-linked immunosorbent assay (ELISA) to quantify VLP’s titer

D) SDS gel electrophoresis to validate VLP’s quality

E) Western blot to ensure VLP’s specificity

VLP    VLP2

Contact Us for More Information
For additional information or to request a project proposal, please contact us at 1-301-476-0885 or <hge@ascentgene.com>. We will be happy to assist you.