Virus like particles (VLPs) represent tremendous potential as vaccine candidates in development of therapeutics for infectious diseases. VLPs possess significant advantages by mimicking the three-dimentional conformation of a natural virus but are non-infectious because of lacking any viral genome packaged inside the capsid.
AscentGene offers VLP production services through our upgraded baculovirus system through the self-assembly mechanism. Ascentgene has been successfully producing high titer (4×1013vlps/ml), high quality (>99% pure) and high activity VLPs with high yield (2 x 1014vlps/L culture) by using either CsCl gradient or chromatography protocols.
Available VLP assays:
A) Hemagglutination assay (HA) to analyze VLP’s activity
B) Electron microscopy (EM) to detect VLP’s conformation
C) Enzyme-linked immunosorbent assay (ELISA) to quantify VLP’s titer
D) SDS gel electrophoresis to validate VLP’s quality
E) Western blot to ensure VLP’s specificity
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For additional information or to request a project proposal, please contact us at 1-301-476-0885 or <email@example.com>. We will be happy to assist you.